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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness (UKR)T. Cohen, M. Murray |
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Mathematical models have recently been used to predict the future burden of multidrug-resistant tuberculosis (MDRTB). These models suggest the threat of multidrug resistance to TB control will depend on the relative «fitness» of MDR strains and imply that if the average fitness of MDR strains is considerably less than that of drug-sensitive strains, the emergence of resistance will not jeopardize the success of tuberculosis control efforts.
Multidrug resistance in M. tuberculosis is conferred by the sequential acquisition of a number of different single-locus mutations that have been shown to have heterogeneous phenotypic effects.
Here we model the impact of initial fitness estimates on the emergence of MDRTB assuming that the relative fitness of MDR strains is heterogeneous. We find that even when the average relative fitness of MDR strains is low and a well-functioning control program is in place, a small subpopulation of a relatively fit MDR strain may eventually outcompete both the drug-sensitive strains and the less fit MDR strains.
These results imply that current epidemiological measures and short-term trends in the burden of MDRTB do not provide evidence that MDRTB strains can be contained in the absence of specific efforts to limit transmission from those with MDR disease.
Keywords: Tuberculosis, fitness, MDR, strain.
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 The problem of tuberculosis in Ukraine (UKR)V.I. Petrenko, R.G. Proziuk |
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Was analyzed tuberculosis epidemical situation in Ukraine. Was found that there is a decrease in tuberculosis morbidity and mortality. Lowest indexes in Ukraine were registered in 1990 (32 cases and 8,1 cases per 100 thousand of population respectively). The morbidity of tuberculosis in Ukraine from 1990 till 2005 increased in 2,7 times (from 8,1 cases per 100 thousand of the population in 1990 to 25,3 in 2005). From 2006 there was reducing in morbidity and mortality. In 2013 the tuberculosis incidence was 67,9 per 100 thousand of the population, that is 19,3 % less than in 2005. The mortality rate was decreased in 44,1% (from 25,3 cases per 100 thousand of the population in 2005 to 14,1 in 2013).
Keywords: tuberculosis, morbidity, mortality.
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Original language: Ukrainian
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Actual questions of implementation substitution maintenance therapy in Ukraine (UKR)M.V. Zelenska, Î.G. Eshenko, I.L. Demchenko |
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Keywords: risk groups, consumers opiate injection drug substitution maintenance therapy, pregnant, monitoring and evaluation of measures, laws and regulations, coordinating councils, the sites of substitution therapy.
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Original language: Ukrainian
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Toxic effect of antituberculosis drugs on vital organs and research of pyridoxine protective actions during antituberculosis drugs intoxication (UKR)L.V. Gaeva |
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Keywords: tuberculosis, indices of infestation, isoniazid, vitamin B6, the optimal mathematical model.
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Original language: Ukrainian
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Contents essential amino acids blood in patients with respiratory tuberculosis during the treatment (UKR)I.O. Galan |
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Keywords: essential amino acids blood, tuberculosis.
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Risk factors of hepatotoxic side reactions in patients with new cases co-infection tuberculosis/HIV in combination with viral hepatitis B and/or C (UKR)S.O. Cherenko, L.Ya. Maniv |
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Keywords: new cases co-infection tuberculosis/HIV, viral hepatitis B and C, hepatotoxic side effects of anti-TB drugs.
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Original language: Ukrainian
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Effects of Asp299Gly TLR-4 gene polymorphism on the condition of antiendotoxin immunity in patients with frequent and rare exacerbations of asthma (RUS)Yu.A. Bisyuk, A.I. Kurchenko |
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Keywords: bronchial asthma, endotoxin, Asp299Gly polymorphism of TLR-4.
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Original language: Russian
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Effectiveness of treatment in patients with new cases of multidrug resistant tuberculosis that diagnosed molecular-genotypic or phenotypic methods (UKR)S.Î. Cherenko, H.Î. Varytska |
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Keywords: multidrug-resistant tuberculosis, bacteriological and molecular genetic diagnosis of tuberculosis.
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Original language: Ukrainian
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Cytological structure of blood in patients with chemical resistant tuberculosis and its value for the evaluate of the intensity of endogenous intoxication (UKR)I.L. Platonovà, E.I. Pysarenko, K.D. Mazhak, Î.À. Tkach, G.D. Shtybel, Î.V. Pavlenko, O.V. Omelyan, T.V. Turchyna, N.I. Kiromasova, L.G. Bozhko |
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Keywords: hemogram of blood, indices of endogenous intoxication, drug resistant tuberculosis (FDTB, RTB).
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Biochemical features of liver’s disfunction in treatmet of patients with destructive pulmonary tuberculosis (UKR)V.I. Zozuliak, N.V. Zozuliak, I.I. Pylypenko |
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Keywords: tuberculosis, destruction, mycobacteriaexcretion, the biochemical indexes of liver’s function.
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Rehabilitation of patients with chronic obstructive pulmonary disease and concomitant spine pathology (UKR)².P. Gumeniuk |
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Keywords: chronic obstructive pulmonary disease, traumatic elements, rehabilitation.
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Risk factors of severe infiltrative pulmonary tuberculosis development in contemporary epidemiologic conditions (RUS)L.D. Todoriko, Å.V. Låsnic, S. Ghinda, O. Caraiani |
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Keywords: tuberculosis, risk factors.
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 The incidence of tuberculosis health workers of Vinnytsya region (UKR)O.P. Litvinuk, S.V. Zaykov, Î.Î. Zakharchenko, T.I. Klimenko |
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Keywords: tuberculosis, health workers, morbidity, Vinnitsya region, Ukraine.
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 The pleural effusion syndrome — a manifestation of tuberculous spondylitis (UKR)I.D. Duzhiy, G.P. Piddubna, L.A. Bondarenko, I.Ya. Gresko, A.V. Yurchenko |
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Keywords: tuberculous pleurisy, tuberculous spondylitis, diagnostics.
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Notice: Undefined index: pict in /home/vitapol/tubvil.vitapol.com.ua/en/svizhij_nomer.php on line 74 Osteoarticular tuberculosis as part of the tuberculosis problem (UKR)G.G. Golka, O.G. Fadeev, D.A. Istomin, V.V. Vesnin |
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Keywords: diagnostic of osteoarticular tuberculosis, radiological investigation methods, improvement of diagnostic.
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Original language: Ukrainian
¹4(31) // 2017